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HESI EXAM 2026

Reading Comprehension (Hard)

1. Which statement best summarizes a paragraph discussing multiple causes of disease transmission?

A. It lists one cause in detail

B. It explains minor details

C. It captures the central idea concisely

D. It quotes the author

2. An inference is most accurately defined as:

A. A direct quote

B. A logical conclusion from evidence

C. A personal opinion

D. A summary

3. What does the author most likely intend by using statistics?

A. To confuse the reader

B. To provide emotional appeal

C. To support an argument

D. To replace examples

4. Which sentence would be considered a bias indicator?

A. According to the study

B. The data shows

C. Clearly, this proves

D. The results indicate

5. Which title best fits an informational passage on infection control?

A. My Hospital Experience

B. Why Nurses Matter

C. Preventing the Spread of Disease

D. Medical School Life

Grammar (Hard)

6. Choose the sentence with correct subject‑verb agreement.

A. The group of nurses are prepared.

B. The group of nurses is prepared.

C. The nurses group are prepared.

D. The nurses group is preparing.

7. Identify the sentence with correct pronoun usage.

A. Everyone forgot their badge.

B. Everyone forgot his or her badge.

C. Everyone forgot there badge.

D. Everyone forgot badges.

8. Select the correctly punctuated sentence.

A. However the test was difficult.

B. However, the test was difficult.

C. However; the test was difficult.

D. However the test, was difficult.

9. Which sentence avoids a sentence fragment?

A. While the nurse was charting.

B. Because the patient was stable.

C. The nurse completed the chart.

D. Although feeling tired.

10. Choose the sentence with proper parallel structure.

A. She likes reading, to jog, and swims.

B. She likes to read, jogging, and swimming.

C. She likes reading, jogging, and swimming.

D. She likes to read, jogging, and to swim.

Math (Hard)

11. A patient needs 0.75 L of fluid. How many mL is this?

A. 75

B. 750

C. 7,500

D. 0.075

12. Order: 1.5 g medication. Available: 500 mg tablets. How many tablets?

A. 1

B. 2

C. 3

D. 4

13. IV order: 1,000 mL over 8 hours. Flow rate?

A. 100 mL/hr

B. 125 mL/hr

C. 150 mL/hr

D. 175 mL/hr

14. Convert 0.25 to a fraction.

A. 1/2

B. 1/3

C. 1/4

D. 3/4

15. A patient weighs 154 lb. Weight in kg? (2.2 lb/kg)

A. 65

B. 68

C. 70

D. 75

Biology (Hard)

16. Which structure regulates what enters and exits the cell?

A. Nucleus

B. Cell membrane

C. Ribosome

D. Mitochondria

17. Which macromolecule is the main energy source?

A. Protein

B. Lipids

C. Carbohydrates

D. Nucleic acids

18. DNA replication occurs during which phase?

A. G1

B. S

C. G2

D. M

19. Which system is responsible for hormone regulation?

A. Nervous

B. Digestive

C. Endocrine

D. Respiratory

20. Which blood cells fight infection?

A. Platelets

B. Red blood cells

C. White blood cells

D. Plasma

Anatomy & Physiology (Hard)

21. Which structure is the pacemaker of the heart?

A. AV node

B. SA node

C. Bundle of His

D. Purkinje fibers

22. Where does gas exchange occur in the lungs?

A. Bronchi

B. Bronchioles

C. Alveoli

D. Pleura

23. Which organ produces insulin?

A. Liver

B. Pancreas

C. Kidney

D. Thyroid

24. What is the primary function of the kidneys?

A. Digestion

B. Oxygen transport

C. Waste filtration

D. Hormone storage

25. Which muscle type is involuntary and striated?

A. Skeletal

B. Smooth

C. Cardiac

D. Voluntary

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